Principal Scientist I/II - Molecular Pathology

7w1 month ago

Novartis

Cambridge, US · Full-time · $108,500 – $201,500

About this role

The Molecular Pathology team within Oncology Translational Research at Biomedical Research is seeking a highly motivated Principal Scientist to develop, validate, and scale novel approaches to characterize protein features of drug targets. This onsite role in Cambridge, MA offers the opportunity to work in a highly collaborative laboratory environment alongside cross-functional teams.

In this role, you will lead efforts to understand how protein features—including proteoforms, localization, conformation, and interactions—impact response and resistance in cancer. You will partner closely with target validation, drug discovery, and translational teams to generate insights from patient samples and translate findings to preclinical models.

Your work will directly contribute to translational strategies across the drug development continuum, from target characterization through biomarker development. The position involves shaping proteomics strategy and technology platforms while identifying novel scientific and methodological opportunities.

Collaboration spans matrixed teams across Oncology Research, Discovery, and Translational Science. The role supports cross-functional initiatives for target understanding and biomarker development in a translational research environment.

Requirements

PhD in Oncology, Cell Biology, Biochemistry, Molecular Biology, or a related discipline
Principal Scientist I: 3+ years of postdoctoral training; Principal Scientist II: postdoctoral training + 3+ years of industry experience
Proven ability to generate data that influences scientific and technical decision-making
Experience with in vitro and in vivo models as well as clinical or post-mortem patient samples
Strong expertise in protein characterization techniques including Western blotting, ELISA, FACS, high-content imaging, and microscopy-based approaches
Experience with methods to probe, label, and enrich proteoforms or related protein features
Curiosity and adaptability to explore emerging technologies and scientific innovations

Responsibilities

Contribute to and help shape proteomics strategy and technology platforms in a translational research environment
Identify and develop novel scientific and methodological opportunities based on literature and internal insights
Design, develop, and scale methods to characterize proteoforms, protein localization, conformation, and protein-protein interactions
Apply approaches to patient-derived samples and define translational relevance in preclinical models
Collaborate across matrixed teams spanning Oncology Research, Discovery, and Translational Science
Lead or contribute to cross-functional initiatives supporting target understanding and biomarker development